Abstract: In recent years, fungal infections have been rampant worldwide, affecting approximately hundreds of millions of people annually, with nearly 1. 5 million deaths, posing a significantthreat to human health. Candida albicans is one of the most important pathogens responsible for fungal infections, and it causes invasive candidiasis with a mortality rate of 40 % -50 % . However, the limited variety of available antifungal drugs and the increasing severity of drug resistance make theclinical treatment of Candida albicans particularly challenging. Therefore, it is particularly importantto search for new antifungal compounds and unique molecular targets for antifungal therapy. This review summarizes some novel antifungal compounds with significant potential against Candida albicansand some new antifungal targets in recent years.

Key words: Candida albicans, drug resistance, mitochondria, biofilm, drug targets