Abstract: FK506-binding protein like ( FKBPL) is a member of the immunophilin family,and its functions are highly diverse. It can regulate the signal transduction of steroid receptors, inhibit the growth of tumor stem cells and tumor cells, and serve as a biological marker for tumor prognosis. Recent research has revealed the presence of an anti-angiogenesis domain in the N-terminal region of FKBPL, indicating its role in regulating angiogenesis both in vivo and in vitro. Additionally, FKBPL is associated with various issues such as inflammation, ocular diseases,and psychological disorders. This review aims to make a summary of the recent researches on FKBPL from the aspects of its structure and functions, and discusses its potential clinical applications.

Key words: FK506-binding protein like, angiogenesis, tumor, endocrine