Role of Integrin Family in Progression of Head and Neck Squamous Cell Carcinoma and Regulation of Its Tumor Microenvironment

doi:10.3870/j.issn.1672-8009.2026.03.013

Abstract

Abstract: Integrins are a class of heterodimeric transmembrane receptors that play a pivotal role in mediating tumor growth,invasion,and drug resistance by interacting with the tumor microenvironment and regulating signaling pathways such as Wnt/β-catenin,FAK,and MAPK.Numerous studies have demonstrated that the expression levels of certain integrins in head and neck squamous cell carcinoma(HNSCC)are closely associated with malignant progression and prognosis.This article reviews the roles of key integrins in the malignant progression and drug resistance of HNSCC,as well as their multidimensional communication between tumor cells,immune cells,and stromal cells within the tumor microenvironment.

Key words: integrin, head and neck squamous cell carcinoma, tumor microenvironment

CLC Number:

R739.91

SUN Yuanyuan, SUN Rui, WANG Jianhao. Role of Integrin Family in Progression of Head and Neck Squamous Cell Carcinoma and Regulation of Its Tumor Microenvironment[J]. Journal of Medical Molecular Biology, 2026, 23(3): 331-336.

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