Abstract: Piezo2, as a member of Piezo channel family, is a fast adaptive and mechanically activated cation channel expressed in the sensory neuron subsets of dorsal root ganglion. It can convert mechanical stimulation into mechanical sensitive current to control the generation of body surface proprioception, touch and pain. Nowadays, more and more studies show that Piezo2 plays an important role in the generation and transmission of a variety of pains. Based on the analysis of previous research results, this paper summarizes the structure and function of mechanically sensitive ion channel Piezo2 and its participation in different pains and the associated diseases, so as to understand the application prospects of using it as a potential intervention target for the treatment of pain.

Key words: Piezo2, mechanical stimulation, mechanically sensitive ion channels, sense of pain