基于离子通道探讨与HPV感染相关致癌因子的研究进展*

doi:10.3870/j.issn.1672-0741.25.08.019

华中科技大学学报（医学版） ›› 2026, Vol. 55 ›› Issue (3): 423-430.doi: 10.3870/j.issn.1672-0741.25.08.019

基于离子通道探讨与HPV感染相关致癌因子的研究进展^*

梁铭阁¹, 艾雯霞^1,2, 亓丁^1,3, 李娜¹, 门昊⁴, 刘丽^1,2△

¹黑龙江中医药大学第一临床医学院,哈尔滨 150040
²黑龙江中医药大学附属第一医院宫腔镜室,哈尔滨 150040
³黑龙江中医药大学附属第二医院妇产科,哈尔滨 150001
⁴郑州大学第二附属医院生殖医学科,郑州 450014

收稿日期:2025-08-10 出版日期:2026-06-15 发布日期:2026-06-17
通讯作者: ^△E-mail:Liuliyouxiang2008@163.com
作者简介:梁铭阁,女,1998年生,博士研究生,E-mail:lmg19982021@163.com
基金资助:
^*教育部“春晖计划”合作科研项目(No.HLJ2019032);黑龙江省省属本科高校中央支持地方高校改革发展项目(No.2021ZYGLG-001);黑龙江省博士后面上项目(No.LBH-Z24287);黑龙江省中医药科研项目(No.ZHY2024138)

Research Progress of Carcinogenic Factors Related to HPV Infection Based on Ion Channels

Liang Mingge¹, Ai Wenxia^1,2, Qi Ding^1,3 et al

¹The First Clinical Medical College of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China
²Hysteroscopy Department, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China
³Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China

Received:2025-08-10 Online:2026-06-15 Published:2026-06-17
Contact: ^△E-mail:Liuliyouxiang2008@163.com

摘要/Abstract

摘要： 离子通道负责离子在细胞膜上的流动,在人体生理中起着非常重要的作用,包括调节离子稳态、电兴奋性和细胞信号传导。当离子通道的功能或表达发生改变时,这些通道与致癌因子相互作用,使机体易感HPV病毒,诱发癌变。该文基于钾、钠及氯离子通道聚焦与HPV病毒相关的致癌因子,阐述相关机理和靶向离子通道的治疗潜力,为临床确定HPV相关癌症的早期诊断、预后和治疗方案提供了新的思路。

关键词: HPV, 离子通道, 致癌因子, 分子标志物, 靶向治疗

Abstract: Ion channels are responsible for the flow of ions across cell membranes and play vital roles in human physiology,including the regulation of ion homeostasis,electrical excitability,and cell signaling.However,when ion channel function or expression is altered,these channels can interact with carcinogens,increasing susceptibility to HPV infection and inducing cancer.Therefore,this study focuses on potassium,sodium,and chloride ion channels,identifies HPV-related carcinogenic factors,elucidates relevant mechanisms and the potential for targeting ion channels for treatment,and provides a new approach to the clinical determination of HPV-related cancer early diagnosis,prognosis,and treatment.

Key words: HPV, ion channel, carcinogenic factor, molecular marker, targeted therapy

中图分类号:

R730.2

梁铭阁, 艾雯霞, 亓丁, 李娜, 门昊, 刘丽. 基于离子通道探讨与HPV感染相关致癌因子的研究进展^*[J]. 华中科技大学学报（医学版）, 2026, 55(3): 423-430.

Liang Mingge, Ai Wenxia, Qi Ding et al. Research Progress of Carcinogenic Factors Related to HPV Infection Based on Ion Channels[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(3): 423-430.

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基于离子通道探讨与HPV感染相关致癌因子的研究进展^*

Research Progress of Carcinogenic Factors Related to HPV Infection Based on Ion Channels

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