三酰甘油-葡萄糖指数与60岁以上老年人轻度认知障碍的相关性研究*

doi:10.3870/j.issn.1672-0741.25.08.005

华中科技大学学报（医学版） ›› 2026, Vol. 55 ›› Issue (1): 116-121.doi: 10.3870/j.issn.1672-0741.25.08.005

三酰甘油-葡萄糖指数与60岁以上老年人轻度认知障碍的相关性研究^*

吴青青^1,2, 种玉飞^1,3,4, 李正良^1,2,5, 龚婧仪¹, 孙佳玲¹, 段璨^1,2,5, 叶艺³, 周芬³, 张雨彤¹, 夏文广^1,2,3,4△

¹湖北中医药大学, 武汉 430061
²湖北中医药大学附属新华医院(湖北省中西医结合医院)康复科, 武汉 430020
³湖北省直属机关医院(湖北省康复医院)神经康复科, 武汉 430061
⁴神经调控技术湖北省工程研究中心, 武汉 430061
⁵湖北省脑卒中后中西医结合康复临床医学研究中心, 武汉 430020

收稿日期:2025-07-30 出版日期:2026-02-15 发布日期:2026-02-10
通讯作者: ^△E-mail:docxwg@163.com
作者简介:吴青青,女,1999年生,硕士研究生,E-mail:wqingqing123@outlook.com
基金资助:
^*湖北省科技厅重大专项(No.2022ACA003-03-004);湖北省科技厅揭榜制科技项目(No.2023BEB005);湖北省自然科学基金指导性计划项目(No.2025AFC125);国家中医药管理局科技专项课题(No.GZY-KJS-2025-001)

Association Between Triglyceride-Glucose Index and Mild Cognitive Impairment in the Elderly

Wu Qingqing^1,2, Chong Yufei^1,3,4, Li Zhengliang^1,2,5 et al

¹Hubei University of Chinese Medicine, Wuhan 430061, China
²Department of Rehabilitation, Xinhua Hospital of Hubei University of Chinese Medicine (Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine), Wuhan 430020, China
³Neurological Rehabilitation Department, The Affiliated Hospital of Hubei Provincial Government(Hubei Rehabilitation Hospital), Wuhan 430061, China
⁴Hubei Engineering Research Center of Neuromodulation Technology, Wuhan 430061, China
⁵Hubei Provincial Clinical Research Center for Stroke Rehabilitation of Integrated Traditional Chinese and Western Medicine, Wuhan 430020, China

Received:2025-07-30 Online:2026-02-15 Published:2026-02-10
Contact: ^△E-mail:docxwg@163.com

摘要/Abstract

摘要： 目的探讨三酰甘油-葡萄糖指数(TyG)与老年人轻度认知障碍(MCI)之间的关系。方法以2023年9月至2024年9月于湖北省武汉市水果湖社区体检的60岁及以上老年人为研究对象,依据纳入与排除标准最终纳入487例受试者。收集研究对象一般资料和实验室资料,计算体质量指数(BMI)和TyG指数。根据蒙特利尔认知评估量表(MoCA)得分将研究对象分为MCI组和正常组。采用两独立样本t检验、Wilcoxon秩和检验、Fisher精确概率法检验进行组间比较。调整了年龄、性别、BMI等混杂因素后采用二元Logistic回归分析TyG指数与MCI的关联,并将年龄与BMI联合分组进行亚组分析。采用限制性立方样条图(RCS)回归评估TyG指数与MCI的剂量-反应关系。结果共纳入受试者MCI组203例,正常组284例。与正常组比较,MCI组的TyG指数显著升高(P<0.05)。二元Logistic回归分析显示,对混杂因素校正后,TyG指数对MCI仍有正向影响(P=0.036),RCS回归分析显示MCI风险随TyG指数升高呈线性上升趋势(P_overall =0.038,P_non-linear>0.05)。年龄与BMI联合分层发现年龄≥70岁且BMI≥24 kg/m²的人群,TyG指数升高与MCI患病风险呈显著正相关。结论 TyG指数升高与MCI患病风险相关,提示TyG指数可作为早期识别MCI的指标。

关键词: 轻度认知障碍, 三酰甘油-葡萄糖指数, 胰岛素抵抗, 老年人, 横断面研究

Abstract: Objective T o investigate the association between the triglyceride-glucose(TyG)index and mild cognitive impairment(MCI)in older adults. Methods Older adults aged ≥ 60 years who underwent health examinations in the Shuiguohu Community of Wuhan,Hubei Province,from September 2023 to September 2024 were enrolled.According to the inclusion and exclusion criteria,487 participants were ultimately included.General demographic characteristics and laboratory data were collected,and body mass index(BMI)and the TyG index were calculated.The participants were divided into an MCI group and a normal cognition group on the basis of the Montreal Cognitive Assessment(MoCA)score.Between-group comparisons were performed via independent-samples t tests,Wilcoxon rank-sum tests,and Fisher’s exact tests.After adjustment for confounders,including age,sex,and BMI,binary logistic regression was used to analyze the association between the TyG index and MCI,and subgroup analyses were conducted according to combined categories of age and BMI.Restricted cubic spline(RCS)regression was applied to evaluate the dose-response relationship between the TyG index and MCI. Results Among the 487 participants,203 were classified into the MCI group,and 284 into the normal group.Compared with that in the normal group,the TyG index was significantly increased in the MCI group(P<0.05).After adjustment for confounding factors,binary logistic regression revealed that the TyG index was positively associated with MCI(P= 0.036).RCS regression indicated a linear increasing trend in MCI risk with increasing TyG index values(P_overall= 0.038,P_non-linear> 0.05).Subgroup analysis on the basis of combined age and BMI data revealed that an elevated TyG index was significantly positively associated with MCI risk among individuals aged ≥70 years with a BMI ≥ 24 kg/m². Conclusion Elevated TyG index is associated with an increased risk of MCI,suggesting that the TyG index may serve as a potential indicator for the early identification of MCI.

Key words: mild cognitive impairment, triglyceride-glucose index, insulin resistance, elderly, cross-sectional study

中图分类号:

R749.16

吴青青, 种玉飞, 李正良, 龚婧仪, 孙佳玲, 段璨, 叶艺, 周芬, 张雨彤, 夏文广. 三酰甘油-葡萄糖指数与60岁以上老年人轻度认知障碍的相关性研究^*[J]. 华中科技大学学报（医学版）, 2026, 55(1): 116-121.

Wu Qingqing, Chong Yufei, Li Zhengliang et al. Association Between Triglyceride-Glucose Index and Mild Cognitive Impairment in the Elderly[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(1): 116-121.

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三酰甘油-葡萄糖指数与60岁以上老年人轻度认知障碍的相关性研究^*

Association Between Triglyceride-Glucose Index and Mild Cognitive Impairment in the Elderly

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