Research Progress on Pathophysiological Functions and Molecular Mechanisms of Lysine Crotonylation Modification

doi:10.3870/j.issn.1672-8009.2026.05.012

Journal of Medical Molecular Biology ›› 2026, Vol. 23 ›› Issue (5): 571-576.doi: 10.3870/j.issn.1672-8009.2026.05.012

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Research Progress on Pathophysiological Functions and Molecular Mechanisms of Lysine Crotonylation Modification

Ahela Halibieke^1,2#, WANG Yue^1#, CAO Dingge¹, SI Wenzhe^1,3

¹Department of Clinical Laboratory, Peking University Third Hospital, Beijing, 100191, China;
²Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking Union Medical College, Beijing, 100730, China;
³NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China

Received:2026-03-16 Online:2026-09-30 Published:2026-09-30
Contact: SI Wenzhe （E-mail：wenzhesi@bjmu.edu.cn）
About author:#:These authors contributed equally as first author.
Supported by:
Beijing Nova Program（No.20260484442）, Beijing Natural Science Foundation（No.7232206）, Peking University Third Hospital Clinical Key Project Innovation A（No.BYSYZD2024011）, Peking University Third Hospital Cross-Disciplinary Joint Special Fund（No.BYSYJC2025060,No.BYSYJC2025018）.

Abstract

Abstract: Post-translational modifications serve as key regulatory mechanisms in functional proteomics, extensively involved in modulating protein activity, subcellular localization, and interactions. Among these, lysine crotonylation is a novel form of modification discovered in recent years, occurring on both histones and non-histone proteins. It participates in critical biological processes such as gene transcription, cell cycle progression, and DNA damage response. This review systematically summarizes the regulatory roles and molecular mechanisms of lysine crotonylation in cardiovascular diseases, respiratory diseases, neurological disorders, as well as kidney diseases, diabetes, autoimmune diseases, and reproductive endocrine-related conditions, aiming to provide a new theoretical foundation and research perspectives for targeted therapeutic strategies of related diseases.

Key words: crotonylation, molecular mechanism, cardiovascular disease, respiratory disease, neurological disease

CLC Number:

R363

Ahela Halibieke, WANG Yue, CAO Dingge, SI Wenzhe. Research Progress on Pathophysiological Functions and Molecular Mechanisms of Lysine Crotonylation Modification[J]. Journal of Medical Molecular Biology, 2026, 23(5): 571-576.

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Research Progress on Pathophysiological Functions and Molecular Mechanisms of Lysine Crotonylation Modification

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