Advances in Researches on RIG-I in Diseases

doi:10.3870/j.issn.1672-8009.2025.06.013

Abstract

Abstract: Retinoic acid-induced gene Ⅰ(RIG-Ⅰ),served as a cytoplasmic pattern recognition receptor,is capable of recognizing RNA viruses,and can activate mitochondrial antiviral signaling protein(MAVS)through conformational changes and trigger the TBK1-IRF3/IKK-NF-κB pathway to induce type I interferon(IFN-Ⅰ)production.Mutations in the RIG-I encoding gene DDX58 or excessive activation of RIG-I can lead to the overproduction of inflammatory mediators such as IFN-I,promoting apoptosis and autoantibody formation,resulting in damage to multiple organs including the heart,brain,and kidneys.The cross-disease role of RIG-I in both infectious and non-infectious diseases has gained significant attention in recent years.This article reviews RIG-Ⅰand its roles in systemic lupus erythematosus,tumors,and cardiovascular diseases.

Key words: RIG-I, innate immunity, autoimmune diseases, tumor, cardiovascular diseases

CLC Number:

WANG Wenliang, TIAN Haiping, LIU Taiyi, WANG Cheng. Advances in Researches on RIG-I in Diseases[J]. Journal of Medical Molecular Biology, 2025, 22(6): 617-622.

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