Abstract: From the perspective of the “Comprehensive Ideological and Political Course”, it is a key strategic measure to fully display the educational effectiveness of the Biochemistry and Molecular Biology course in medical colleges and promote the integration and innovation of the “ Comprehensive Social Classroom” and the “Ideological and Political Education in Small Classrooms” to achieve the achieve the fundamental task of forstering virtue through education. Based on the characteristics of the teaching content of Biochemistry and Molecular Biology and the “BOPPPS” teachingmodel, this study takes internal drive, humanistic charm, scientific view, world eye, and Chinese heart as the top-level design of ideological and political education in the course. In addition, it adopts the dual strategies of “bringing in and going out”, making full use of social resources such as museums and red culture bases, besides innovating the ideological and political education classroom in the course with the teaching method of knowledge and ideology spiraling upward. In conclusion, the research results show that this innovative model significantly improves the effectiveness of ideological and political education in the course, enhances students’ideological realm and comprehensive quality, and provides new ideas and practical examples for the implementation of curriculum ideological and political education in the whole domain of biochemistry and molecular biology course under the perspective of “Comprehensive Ideological and Political Education” .

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