Abstract: Aspergillus fumigatus (A. fumigatus) is the most prevalent airborne fungal pathogenand can cause fatal invasive aspergillosis in immunocompromised patients. The interaction of the pathogen with the host immune system is a key process in understanding pathogenicity. Recognition of conserved molecular structures on the surface of pathogens by conserved transmembrane or soluble pattern recognition receptors ( PRRs ) is referred to as pathogen-associated molecular patterns (PAMPs). C-type lectin receptors ( CLRs) are one of the major receptor families in PRRs, and CLRs can recognize fungal cell wall components such as β-glucan, mannose, and chitin through Ctype lectin-like domains ( CTLDs), thus inducing both innate and acquired immunity to clearpathogens. Currently, the main CLRs involved in A. fumigatus are Dectin-1, Dectin-2, MelLec, DC-SIGN, etc. These CLRs play a crucial role in host cell recognition of A. fumigatus, and novelanti-fumigatus drugs have been developed against Dectin-1 and Dectin-2. Therefore, further understanding of the effect of various CLRs associated with A. fumigatus and its mechanism and the relatedsignaling pathways will provide us new perceptions for the development of novel antifungal drugs. Inthis case, this paper presents a review of the latest research progress of CLRs related to Aspergillus fumigatus.

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