Abstract: About half of the global population has been found to be infected with Helicobacter pylori (H. pylori), with particularly high rates in developing countries. Currently, H. pylori infection has been listed as a high-risk factor for the development of gastric cancer. The pathogenesis of H. pylori infection is believed to be associated with complex interactions between environment factors, host susceptibilities, and bacterial pathogenicity. Therefore, this article reviews the molecularmechanism of the regulation of Helicobacter pylori independent factor cagA expression, in order tobetter understand the pathogenicity of cagA and to provide a theoretical reference for the future prevention and treatment of diseases caused by H. pylori.

Key words: Helicobacter pylori, cytotoxin-associated gene A, regulatory mechanism