Journal of Medical Molecular Biology ›› 2023, Vol. 20 ›› Issue (5): 462-466.doi: 10.3870/j.issn.1672-8009.2023.05.014

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Advances in Research on tRNA-derived Small RNA in Tumors 

  

  1. Department of Respiratory Disease, the Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, 315000, China
  • Online:2023-09-30 Published:2023-11-13

Abstract: ransfer RNA-derived small RNA ( tsRNA) is a novel non-coding RNA stably expressed in human tissues. The tRNA halves and the tRNA-derived RNA fragment are known as the two tsRNA subtypes. The development and application of high-throughput sequencing technology have provided more and more evidence for tsRNA dysregulation in tumors. Abnormal expression of tsRNA in tumor tissues has been found to be related to the tumor proliferation, invasion and progression. Therefore, these newly discovered tsRNAs have great potential as novel biomarkers and targets for the treatment of cancer. This article reviews the latest research progress of tsRNA in tumors and discusses its potential clinical values.

Key words: tRNA, non-coding RNA, tRNA-derived small RNA, cancer

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