Abstract: Objective To detect the expression level of COX7B2 in metastatic ovarian cancer, explore its expression pattern, determine the effect of COX7B2 on the prognosis of ovarian cancer, and analyze its potential value as a diagnostic marker for ovarian cancer. Methods The RNA expression level of COX7B2 in ovarian cancer were analyzed in TCGA database. The expression of COX7B2 protein in ovarian cancer tissue samples from Handan Central Hospital was analyzed by immunohistochemical staining. Combined with the survival data, the clinical staging and prognosis were analyzed. The correlation between the expression of COX7B2 and the immune cell infiltration was analyzed. Results COX7B2 was highly expressed in ovarian cancer tissues especially in the tissues of metastatic ovarian cancer. The expression level of COX7B2 was correlated with the patient histological grade, pathological stage, lymph node metastasis, distal metastasis, and the patient survival time. The diagnosis of ovarian cancer by the expression of COX7B2 had a high accuracy. COX7B2 inhibited the infiltration of T cells, NK cells, and DC cells in the tumor microenvironment. Conclusion The COX7B2 is highly expressed in the ovarian cancer tissues, which affects the prognosis of patients. COX7B2 is expected to be served as a diagnostic marker for ovarian cancer, as well as a characteristic marker for the metastatic ovarian cancer.

Key words: ovarian cancer, COX7B2, metastasis