Abstract: Protein glycosylation is a wide range of post-translational modifications, with the involvement of the synthesis of different polysaccharide cores and the attachment of which to particular amino acids within a protein consensus sequences. Most glycoproteins acquire glycosyl groups from the secretory system includes endoplasmic reticulum and Golgi apparatus, they are then secreted to the plasma membrane-associated cell wall or extracellular spaces. Glycosylation can regulate the function of glycoproteins by affecting their folding, sorting, localization, abundance and activity in cells. In recent years, many studies have reported that glucose metabolism have an effect on the protein glycosylation. This paper reviews the relationship between hexosamine biosynthesis pathway and the protein glycosylation. 

Key words: glycosylation, glucose metabolism, hexosamine biosynthesis pathway