Abstract: Helicobacter pylori (HP) is a major pathogen responsible for various gastrointestinaldiseases, and its eradication plays a critical role in preventing gastric cancer. The resistance of HP to clarithromycin has become a key issue affecting its eradication. This article reviews the main molecular mechanisms of HP resistance to clarithromycin, aiming to provide a theoretical foundation for optimizing treatment strategies and future antimicrobial research.

Key words: Helicobacter pylori, clarithromycin, resistance mechanism