Abstract: Regulatory T cells ( Tregs) play multifaceted roles in hepatic inflammatory injury. On one hand, Tregs can migrate to inflamed hepatic tissues via chemokine-mediated chemotaxis, exerting immunosuppressive functions and promoting tissue repair. On the other hand, during the fibrotic process induced by inflammatory injury, the interactions between Tregs and other immune cells can counteract fibrogenesis. This review focuses on the classification and functions of Tregs, their specific roles in hepatic inflammatory injury diseases, and the underlying mechanisms mediating their actions in hepatic inflammation and injury, to elucidate the intricate mechanisms by which Tregs modulate hepatic inflammatory injury and further clarify the complexity of hepatic immune cell interactions.

Key words: regulatory T cells, hepatic inflammatory injury, immune suppression