Abstract: Atherosclerosis is the main pathological basis for cerebral infarction, coronary arteryatherosclerotic heart disease and other cardiovascular and cerebrovascular diseases. The abnormal death and functional disorder of vascular endothelial cells play an important role in it. Ferroptosis is a novel type of programmed cell death discovered in 2012, and there have been many studies showing that it plays an important role in the functional disorder and abnormal death of endothelial cells leading to AS. This review summarizes the mechanisms of ferroptosis and the possible mechanisms by which vascular endothelial cell ferroptosis leads to AS, and the drugs that may affect endothelial cell ferroptosis, providing a theoretical basis and research direction for the prevention and treatment of AS in clinical practice.

Key words: vascular endothelial cells, ferroptosis, atherosclerosis