Abstract: Objective To investigate the changes and clinical significance of serum leukocytederived chemotaxin 2 (LECT2) and fibroblast growth factor 21 (FGF-21) in patients with type 2diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease ( NAFLD). Methods A total of 142 T2DM patients admitted to the General Hospital of the Western Theater Region of the People’s Liberation Army of China from October 2019 to October 2021 were divided into 2 groups according to whether complicated with NAFLD: with-NAFLD group (68 cases) and without-NAFLD group (74 cases). Clinical indicators of the patients were collected, and the levels of LECT2 and FGF-21 were detected by ELISA. The differences in clinical indicators between the two groups were compared, and the correlations between the levels of LECT2 and FGF-21 and the other clinical indicators were analyzed. Logistic regression analysis was used to analyze the independent influencing factors of T2DM with NAFLD. ROC curve was used to analyze the efficacy of each variable in predicting T2DM with NAFLD. Results The values of BMI, WHR, SBP, DBP, FPG, FINS, FCP,HbAlc, HOMA-IR, TC, TG, LDL-C, ALT, AST, GGT, LECT2 and FGF21 in the withNAFLD group were higher than those in the without-NAFLD group, the values of HOMA-β andHDL-C were lower than those in the without-NAFLD group (P< 0. 05). Correlation analysis showedthat the level of LECT2 was positively correlated with the values of BMI, WHR, FPG, FINS, FCP, HbAlc, HOMA-IR, TC, GGT, and was negatively correlated with the values of HOMA-βand HDL-C (P<0. 05). The level of FGF21 was positively correlated with the values of FPG, FINS,FCP, HbAlc, HOMA-IR, TC and TG, but negatively correlated with the values of HOMA-β andHDL-C (P<0. 05). Logistic analysis showed that HOMA-IR, HDL-C, LECT2 and FGF21 were independent influencing factors of T2DM with NAFLD (P<0. 05). ROC curve analysis showed that theoptimal truncation values of LECT2 and FGF21 for predicting T2DM with NAFLD were 30. 72 ng / mL and 138. 66 ng / L, with 72. 61 % and 71. 36 % sensitivity and 72. 54 % and 73. 75 % specificity, respectively. The AUC values for LECT2 and FGF21 were 0. 732 and 0. 753, respectively. And the combined sensitivity, specificity and AUC values were 85. 72 % , 87. 44 % and 0. 863, respectively(P<0. 001). Conclusion LECT2 and FGF-21 are correlated with insulin resistance indicators andlipid levels, which can be used as indicators to predict T2DM with NAFLD.

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