Abstract: Objective To explore expressions of miRNA-218 (miR-218) and miR-21 in gastric cancer related to Helicobacter pylori (Hp) infection and their clinical significance. Methods A total of 104 patients with gastric cancer undergoing surgical resection were enrolled. The relationship between miR-218, miR-21 and clinicopathological factors and postoperative recurrence was analyzed. Results The expression Level of miR-218 was lower in the Hp-positive group than in theHp-negative group, while the expression level of miR-21 and the 2-year recurrence rate were higherin the Hp-positive group (P < 0. 05). The expression level of miR-218 was lower in the gastric cancer tissues than in the para-carcinoma tissues, while the expression level of miR-21 was higher in thegastric cancer tissues (P < 0. 05). The expression levels of miR-218 and miR-21 were correlated withthe differentiation degree, TNM staging, depth of tumor invasion, lymph node metastasis and progression-free survival rate, which were of high predictive value for the 2-year recurrence situation after surgery. Conclusion The expression levels of miR-218 and miR-21 are different between gastric cancer patients with or without Hp-infection. The abnormal expressions of miR-218 and miR-21 are related with the clinicopathological factors and prognosis of gastric cancer patients with Hp infection.

Key words: