Abstract: Pleural fibrosis occurs during the recovery phase of tuberculous pleurisy and is oftenprogressive and irreversible, resulting in restricted ventilation dysfunction that significantly affects the quality of life. Therefore, early assessment of the disease and inhibition of the progression of pleural fibrosis are ways for the treatment of tuberculous pleurisy in the future. Although the regulatory mechanism of tuberculous pleural fibrosis has not been systematically elucidated, relevant studies have shown that many important growth factors are involved in the occurrence and development of tuberculous pleural fibrosis. The involved growth factors mainly include transforming growth factor beta (TGF-β), vascular endothelial growth factor ( VEGF), platelet-derived growth factor ( PDGF), fibroblast growth factor (FGF), connective tissue growth factor (CTGF), hepatocyte growth factor (HGF). This article reviews the research progress of tuberculous pleurisy and tuberculous pleural fibrosis, as well as the expression of TGF-β, VEGF, PDGF, FGF and CTGF in tuberculous pleural fibrosis and their possible regulatory mechanisms.

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