Abstract: Objective To explore the effect of chordin-like1 (CHRDL1) on the progression of colorectal cancer ( CRC). Methods The relationship between CHRDL1 and CRC progression, prognosis was analyzed by the database. SW480 and HT29 cell lines with CHRDL1 overexpression were constructed. The cell proliferation, migration and invasion were assayed. The tumor growth was detected byin vitrotumor transplantation assay. The mechanism of CHRDL1 overexpression on migration and invasion of CRC cells was analyzed. Results The expression of CHRDL1 was up-regulated in CRC progression and could affect the prognosis. The overexpression of CHRDL1 could promote cell proliferation, migration, invasion and growth of the transplanted tumors. Its overexpression could also promote the enhanced expressions of Vimentin, N-Cadherin and snail, and inhibit the expression of E-Cadherin. There was an interaction between CHRDL1 and snail. Interfering with snail siRNA could reverse the trend of the above indexes. Conclusion CHRDL1 can promote the proliferation of CRC cells, it can also promote the epithelial mesenchymal transformation of CRC cells and the cell migration and invasion by Snail.

Key words: colorectal cancer, chordin-like1, cell proliferation, migration, invasion