Abstract: Renal cell carcinoma (RCC) affects all human beings profoundly and extensively. Clear cell renal cell carcinoma ( ccRCC) is the most common pathological subtype of RCC. In the past 30 years, the biomolecular mechanisms of RCC have been continuously explored. With the in-depth research on DNA repair pathways, the correlates between RCC and the DNA repair genes were gradually discovered. Cells were always exposed to various factor which could lead to the genome damages, and the DNA repair system helps to maintain the genome stability in that process. If the DNA repair system is defective, the genome will become unstable, cells will undergo apoptosis or transform into cancer cells. This review focuses on the important biological correlates between DNA repair genes (DRG) and ccRCC in the susceptibility, prognosis, and treatment of ccRCC. It could help lay a certain foundation for the further exploration of molecular mechanisms between DNA damage repair pathways and ccRCC, the determination of new ccRCC molecular markers, and the finding of suitable immunosuppressive therapeutic targets. 

Key words: clear cell renal cell carcinoma, DNA repair genes, biological correlates