Sonic Hedgehog信号通路在血管性认知障碍中作用的研究进展*

doi:10.3870/j.issn.1672-0741.25.08.008

华中科技大学学报（医学版） ›› 2026, Vol. 55 ›› Issue (3): 450-456.doi: 10.3870/j.issn.1672-0741.25.08.008

• 综述 • 上一篇

Sonic Hedgehog信号通路在血管性认知障碍中作用的研究进展^*

王家欣¹, 李彦杰^2△, 杨宁^3△, 杨新宇¹, 郭佳¹, 魏胜楠¹

¹河南中医药大学康复医学院,郑州 450046
²河南省中医院康复科,郑州 450002
³郑州人民医院康复科,郑州 450003

收稿日期:2025-08-01 出版日期:2026-06-15 发布日期:2026-06-17
通讯作者: ^△E-mail:yanjieli2008@126.com(李彦杰);yangningzy2013@163.com(杨宁)
作者简介:王家欣,女,2000年生,硕士研究生,E-mail:wangjiaxin0222@163.com
基金资助:
^*国家中医药管理局科技项目(No.GZY-KJS-2022-043-3);河南省自然科学基金面上项目(No.242300420111);河南省“双一流”创建工程中医学学科项目(No.HSRP-DFCTCM-2023-3-11)

Research Progress on the Role of the Sonic Hedgehog Signaling Pathway in Vascular Cognitive Impairment

Wang Jiaxin¹, Li Yanjie^2△, Yang Ning^3△ et al

¹Medical College of Rehabilitation, Henan University of Chinese Medicine, Zhengzhou 450046, China
²Department of Rehabilitation, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China
³Department of Rehabilitation, Zhengzhou People’s Hospital, Zhengzhou 450003, China

Received:2025-08-01 Online:2026-06-15 Published:2026-06-17
Contact: ^△E-mail:yanjieli2008@126.com;yangningzy2013@163.com

摘要/Abstract

摘要： 血管性认知障碍作为一种高发病率、高致残性的脑血管相关疾病,对患者、家庭及社会均造成沉重负担。Sonic Hedgehog信号通路可参与调控血管性认知障碍的多种病理生理过程,被认为是极具前景的治疗靶点。该文对近几年关于Sonic Hedgehog信号通路参与调节血管性认知障碍的作用机制进行综述,旨在阐明其在调节血管性认知障碍多种机制中的关键作用,以期为今后血管性认知障碍的基础研究和临床应用提供新的思路。

关键词: 血管性认知障碍, Sonic Hedgehog信号通路, 血管生成, 髓鞘再生, 突触重塑

Abstract: Vascular cognitive impairment is a cerebrovascular-related disorder with high prevalence and disability,imposing a substantial burden on patients,families,and society.The Sonic Hedgehog signaling pathway is involved in multiple pathophysiological processes relevant to vascular cognitive impairment and has emerged as a highly promising therapeutic target.This review summarizes recent advances in elucidating the mechanisms by which the Sonic Hedgehog signaling pathway modulates vascular cognitive impairment,aiming to clarify its critical role and provide new insights to guide future basic research and clinical translation in this field.

Key words: vascular cognitive impairment, Sonic Hedgehog signal transduction, angiogenesis, remyelination, synaptic plasticity

中图分类号:

王家欣, 李彦杰, 杨宁, 杨新宇, 郭佳, 魏胜楠. Sonic Hedgehog信号通路在血管性认知障碍中作用的研究进展^*[J]. 华中科技大学学报（医学版）, 2026, 55(3): 450-456.

Wang Jiaxin, Li Yanjie, Yang Ning et al. Research Progress on the Role of the Sonic Hedgehog Signaling Pathway in Vascular Cognitive Impairment[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(3): 450-456.

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Sonic Hedgehog信号通路在血管性认知障碍中作用的研究进展^*

Research Progress on the Role of the Sonic Hedgehog Signaling Pathway in Vascular Cognitive Impairment

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