基于周边离焦阐述角膜塑形镜控制近视进展的机制*

doi:10.3870/j.issn.1672-0741.25.08.029

华中科技大学学报（医学版） ›› 2026, Vol. 55 ›› Issue (1): 134-139.doi: 10.3870/j.issn.1672-0741.25.08.029

基于周边离焦阐述角膜塑形镜控制近视进展的机制^*

方登琴, 向艳^△

华中科技大学同济医学院附属同济医院眼科, 武汉 430030

收稿日期:2025-08-19 出版日期:2026-02-15 发布日期:2026-02-10
通讯作者: ^△E-mail:xyz2000832@163.com
作者简介:方登琴,女,2000年生,硕士研究生,E-mail:1971233898@qq.com
基金资助:
^*湖北省自然科学基金资助项目(No.2021CFB342);湖北省卫生健康委员会科研资助项目(No.WJ2021M114)

The Role of Peripheral Defocus in the Mechanism of Orthokeratology for Myopia Control

Fang Dengqin, Xiang Yan^△

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Received:2025-08-19 Online:2026-02-15 Published:2026-02-10
Contact: ^△E-mail:xyz2000832@163.com

摘要/Abstract

摘要： 近年来,近视患病率高发且低龄化,近视防控刻不容缓。角膜塑形镜(orthokeratology,OK镜)是近视防控的关键有效手段之一,其防控机制尚不完全清楚,大多观点认为角膜塑形离焦技术所产生的角膜相对屈光力改变,诱导视网膜周边离焦、脉络膜效应是延缓眼轴增长的有效机制。该文将基于周边离焦理论,对角膜塑形后视网膜周边离焦及脉络膜效应的变化、视网膜周边离焦的检测、周边离焦量大小的影响因素及其与近视防控效果的相关性进行总结归纳,阐述角膜塑形防控近视有效性的作用机制。

关键词: 角膜塑形镜, 视网膜周边离焦, 周边脉络膜厚度

Abstract: In recent years,the increasing prevalence and early onset of myopia have made its control a pressing public health priority.Orthokeratology(OK lenses)is regarded as one of the key effective strategies for myopia management,although its exact mechanisms of action remain incompletely understood.The predominant hypothesis is that orthokeratology modifies the relative optical power of the cornea,thereby inducing peripheral retinal defocus and associated choroidal changes,which together contribute to slowing axial elongation.Grounded in peripheral defocus theory,this article reviews alterations in retinal peripheral defocus and the choroidal response following orthokeratology,discusses methods for assessing retinal peripheral defocus,examines factors influencing the magnitude of defocus,and explores its correlation with myopia control outcomes.The objective of this study is to clarify the mechanism through which orthokeratology effectively mitigates myopia progression.

Key words: orthokeratology, peripheral retinal defocus, peripheral choroidal thickness

中图分类号:

R778.11

方登琴, 向艳. 基于周边离焦阐述角膜塑形镜控制近视进展的机制^*[J]. 华中科技大学学报（医学版）, 2026, 55(1): 134-139.

Fang Dengqin, Xiang Yan. The Role of Peripheral Defocus in the Mechanism of Orthokeratology for Myopia Control[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(1): 134-139.

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基于周边离焦阐述角膜塑形镜控制近视进展的机制^*

The Role of Peripheral Defocus in the Mechanism of Orthokeratology for Myopia Control

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