新型模型动物斑马鱼在颅内动脉瘤研究中的应用*

doi:10.3870/j.issn.1672-0741.25.07.045

华中科技大学学报（医学版） ›› 2026, Vol. 55 ›› Issue (1): 122-128.doi: 10.3870/j.issn.1672-0741.25.07.045

新型模型动物斑马鱼在颅内动脉瘤研究中的应用^*

郑扬, 宁国柱^△, 张晶晶^△

广东医科大学附属医院, 湛江市斑马鱼发育与疾病模型重点实验室, 湛江 524001

收稿日期:2025-07-23 出版日期:2026-02-15 发布日期:2026-02-10
通讯作者: ^△E-mail:ningguozhu@gdmu.edu.cn(宁国柱);jingjing.zhang@gdmu.edu.cn(张晶晶)
作者简介:郑扬,男,1998年生,硕士研究生,E-mail:zhengy202207@163.com
基金资助:
^*国家自然科学基金资助项目(No.32222028);广东医科大学附属医院人才孵化基金资助项目(No.2081Z20230015)

The Application of the New Zebrafish Model in the Study of Intracranial Aneurysms

Zheng Yang, Ning Guozhu^△, Zhang Jingjing^△

Affiliated Hospital of Guangdong Medical University, Zhanjiang Key Laboratory of Zebrafish Model for Development and Disease, Guangdong Medical University, Zhanjiang 524001, China

Received:2025-07-23 Online:2026-02-15 Published:2026-02-10
Contact: ^△E-mail:ningguozhu@gdmu.edu.cn(宁国柱);jingjing.zhang@gdmu.edu.cn(张晶晶)

摘要/Abstract

摘要： 传统的模型动物在颅内动脉瘤遗传操作、发育可视化及高通量筛选领域有一定局限性,斑马鱼这一新型模型动物的出现则丰富了这些领域的研究思路与实验平台。该文系统分析了利用斑马鱼研究人类脑血管疾病的生物学基础,总结了目前若干种成熟的斑马鱼动脉瘤模型,并介绍了其在颅内动脉瘤机制研究中的应用。不同于以往综述平行对比各模型的构建方式和优劣,该文还着重介绍了斑马鱼动脉瘤模型在疾病机制研究上的应用成果,旨在推进斑马鱼模型在颅内动脉瘤机制研究和药物筛选中的应用。

关键词: 颅内动脉瘤, 脑出血, 斑马鱼, 血小板源性生长因子B

Abstract: Traditional animal models have inherent limitations in the genetic manipulation,developmental visualization,and high-throughput screening for intracranial aneurysms(IAs).The emergence of the zebrafish model has been expanding the experimental approaches and research platforms available in these fields.This review systematically analyzes the biological basis of using zebrafish to investigate human cerebrovascular diseases,summarizes several established zebrafish aneurysm models,and introduces their applications in studies of IA mechanisms.Unlike previous reviews that mainly compared the construction methods and strengths of different models in parallel,this paper also focuses on the applications of zebrafish aneurysm models in studying disease mechanisms,aiming to promote a broader application in IA pathogenesis research and drug screening.

Key words: intracranial aneurysm, intracerebral hemorrhage, zebrafish, PDGFRB

中图分类号:

R651.122

郑扬, 宁国柱, 张晶晶. 新型模型动物斑马鱼在颅内动脉瘤研究中的应用^*[J]. 华中科技大学学报（医学版）, 2026, 55(1): 122-128.

Zheng Yang, Ning Guozhu, Zhang Jingjing. The Application of the New Zebrafish Model in the Study of Intracranial Aneurysms[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(1): 122-128.

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新型模型动物斑马鱼在颅内动脉瘤研究中的应用^*

The Application of the New Zebrafish Model in the Study of Intracranial Aneurysms

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