内源性谷氨酸及γ-氨基丁酸能递质系统:治疗心律失常的新靶点*

doi:10.3870/j.issn.1672-0741.25.04.039

华中科技大学学报（医学版） ›› 2026, Vol. 55 ›› Issue (1): 146-148.doi: 10.3870/j.issn.1672-0741.25.04.039

• 综述 • 上一篇

内源性谷氨酸及γ-氨基丁酸能递质系统:治疗心律失常的新靶点^*

刘小慧, 徐梓琴, 何苗苗, 方琴^△

华中科技大学同济医学院附属同济医院心血管内科, 武汉 430030

收稿日期:2025-04-23 出版日期:2026-02-15 发布日期:2026-02-10
通讯作者: ^△E-mail: fangqin140716@126.com
作者简介:刘小慧,女,1998年生,博士研究生,E-mail:lxhzxyls@163.com
基金资助:
^*国家自然科学基金青年基金项目(No.8200340)

Endogenous Glutamatergic and GABAergic System:Novel Intervention Targets for Cardiac Arrhythmias

Liu Xiaohui, Xu Ziqin, He Miaomiao et al

Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Received:2025-04-23 Online:2026-02-15 Published:2026-02-10
Contact: ^△E-mail: fangqin140716@126.com

摘要/Abstract

摘要： 心律失常是世界上最常见的死亡原因之一,大多数抗心律失常药物缺乏特异性,并且有诸多不良反应。更重要的是,几乎所有的抗心律失常药物都有潜在的致心律失常作用,其表现形式可能是使既有的心律失常恶化,也可能诱发新的心律失常。谷氨酸能递质系统及γ-氨基丁酸能递质系统作为新的内源性调节机制,赋予心肌细胞独特的功能可塑性。阐明其在心脏组织中的多重生物学作用,以及识别导致其失调的因素,将对开发针对这一多功能内源性心脏节律调控系统的新治疗策略至关重要。

关键词: 心律失常, 谷氨酸能递质系统, γ-氨基丁酸能递质系统

Abstract: Cardiac arrhythmia is one of the most common causes of death worldwide.Most antiarrhythmic drugs lack specificity and are associated with numerous adverse effects.More importantly,nearly all antiarrhythmic drugs possess potential arrhythmogenic properties,which may exacerbate existing arrhythmias or induce new ones.The glutamatergic and GABAergic systems,as novel endogenous regulatory mechanisms,confer distinct functional plasticity in cardiomyocytes.Elucidating the diverse biological roles of the glutamatergic and GABAergic systems in cardiac tissues,as well as identifying the conditions that lead to their dysregulation,is critical for the development of novel therapeutic strategies targeting this rhythm-regulating system in the heart.

Key words: cardiac arrhythmias, glutamatergic system, GABAergic system

中图分类号:

R541.7

刘小慧, 徐梓琴, 何苗苗, 方琴. 内源性谷氨酸及γ-氨基丁酸能递质系统:治疗心律失常的新靶点^*[J]. 华中科技大学学报（医学版）, 2026, 55(1): 146-148.

Liu Xiaohui, Xu Ziqin, He Miaomiao et al. Endogenous Glutamatergic and GABAergic System:Novel Intervention Targets for Cardiac Arrhythmias[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(1): 146-148.

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内源性谷氨酸及γ-氨基丁酸能递质系统:治疗心律失常的新靶点^*

Endogenous Glutamatergic and GABAergic System:Novel Intervention Targets for Cardiac Arrhythmias

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