Correlation of Serum Defensin 5 Level and Severe Acute Pancreatitis Complicated with Peripancreatic Necrosis

doi:10.3870/j.issn.1672-8009.2025.06.011

Abstract

Abstract: Objective To study the correlation of serum defensin 5 level and severe acute pancreatitis(SAP)complicated with peripancreatic necrosis. Methods A retrospective study was conducted on 224 SAP patients admitted to Kunshan Hospital of Traditional Chinese Medicine from May 2020 to December 2023,and they were divided into peripancreatic necrosis group(n=96)and non-peripancreatic necrosis group(n=128)according to whether peripancreatic necrosis infection occurred.Compare the differences in general characteristics,and serum defensin 5 levels and laboratory indicators within 24 hours of admission between the two groups.Logistic regression was used to analyze the influencing factors of SAP combined with peripancreatic necrosis,and receiver operating characteristics(ROC)curve was used to analyze the diagnostic indicators of peripancreatic necrosisn. Results The levels of serum defensin 5 and serum calcium in the peripancreatic necrosis group were lower than those in the non-peripancreatic necrosis group,and the time from onset to hospital admission,the levels of C-reactive protein(CRP)and procalcitonin(PCT)were higher than those in the non-peripancreatic necrosis group(P<0.05).Logistic regression analysis showed that the level of serum defencin 5,the time from onset to admission,and the levles of serum calcium,CRP and PCT were the influencing factors of peripancreatic necrosis(P<0.05).ROC curve analysis demonstrated that serum defensin 5 level,time from symptom onset to admission,serum calcium levels,CRP,and PCT levels—both individually and in combination—possess diagnostic value for SAP complicated by peripancreatic necrosis infection.The combined diagnostic approach achieved a sensitivity of 82.81 % and a specificity of 96.99 %. Conclusion The decrease of serum defensin 5 level is related to SAP complicated with peripancreatic necrosis.The combination of defensin 5 and time from onset to hospital admission,serum calcium,CRP and PCT have better diagnostic efficacy for SAP complicated with peripancreatic necrosis.

Key words: severe acute pancreatitis, peripancreatic necrosis, defensin 5, influencing factors, diagnosis

CLC Number:

R657.5

ZHANG Hongyan, CHEN Hui. Correlation of Serum Defensin 5 Level and Severe Acute Pancreatitis Complicated with Peripancreatic Necrosis[J]. Journal of Medical Molecular Biology, 2025, 22(6): 607-611.

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