Abstract: Objective To analyze the expression of mitochondrial calcium uniporter regulator 1 (MCURl) in triple-negative breast cancer (TNBC) and its clinical significance. Methods  Immunohistochemistry was used to detect the expression of MCUR1 protein in TNBC tissues and corresponding adjacent tissues of 98 patients. The relationship between MCURl expression in tumor tissuesand patients’clinicopathological features and overall survival was further analyzed. Results  MCUR1was overexpressed in TNBC, and its expression level was significantly higher than that in the adjacent tissues (t = 34. 58, P < 0. 01). Clinicopathological analysis showed that high MCUR1 expression in TNBC was significantly correlated with tumor grade, T stage, and TNM stage ( P 0. 05,respectively). Further survival analysis showed that patients with high expression level of MCUR1had a lower overall survival rate than those with low expression level ( χ2 = 4. 591, P = 0. 032), which was an independent risk factor for poor prognosis of TNBC (HR = 2. 106, 95 % CI: 1. 013-5. 628, P = 0. 035). Conclusion  The expression of MCUR1 in TNBC tissues is up-regulated, andits high expression is associated with tumor progression and poor prognosis, which is a potential biomarker to evaluate the prognosis of TNBC patients.

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