Abstract: Aspergillus fumigatus ( A. fumigatus) is an opportunistic pathogen widely found innature and can cause invasive aspergillosis (IA), with a high mortality rate in immunocompromisedpatients. Triazoles are the first-line therapy for IA, but in recent years, the number of azole-resistant Aspergillus fumigatus isolates is increasing worldwide, which greatly threatens the life and healthof patients. Efflux pumps are composed of transmembrane proteins that can expel unwanted substances out of cells, which is an important mechanism in protecting microorganisms. In addition, many studies suggest that efflux pumps can also mediate microbial drug resistance. This paper summarizes the recent progress on the function and regulation mechanism of the drug efflux pump ofA. fumigatus, which provides a theoretical basis for the deep understanding of the resistance mechanism in A. fumigatus and the screening of new targets of anti-infective drugs.

Key words: Aspergillus fumigatus, drug resistance, efflux pump