Journal of Medical Molecular Biology ›› 2024, Vol. 21 ›› Issue (5): 487-491.doi: 10.3870/j.issn.1672-8009.2024.05.016

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Research Progress of KCNQ1 Channel Structure and Function #br#

  

  1. 1Jiangxi Provincial Key Laboratory of Molecular Medicine, Nanchang, 330006, China  2Department of Medical Genetics, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China
  • Online:2024-09-30 Published:2024-10-25

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Abstract: The KCNQ1 channel is a voltage-gated potassium channel subunit, which is assembled with the proteins of KCNE family to form a functional potassium channel. Changes in the structure and function of KCNQ1 channels affect the pathophysiological processes of various diseases in vivo. In this paper, the structure of KCNQ1, its role in various molecular biological processes, andthe interaction between KCNQ1 and the KCNE family or non-KCNE family are discussed, and the biophysical research progress on KCNQ1 channels are summarized systematically.

Key words: voltage potassium ion channel, KCNQ1, KCNE1, channelopathy

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