Abstract: Objective To investigate the effect of long-chain noncoding RNA small nucleolar RNA host gene 11 ( SNHG11) on the proliferation of colorectal cancer and its molecular mechanism. Methods SNHG11 overexpression or knock-down cell lines were constructed in human colon cancer cell lines LoVo and SW480. The proliferation ability of the colorectal cancer cells was assayed after SNHG11 overexpression or knock-down. The expression levels of P50, P65 and NF-κB downstream signaling proteins were detected after overexpression and interference of SNHG11 in colorectal cancer cell lines. Results Overexpression of SNHG11 could promote the proliferation of colorectal cancer cells, while inhibition of SNHG11 expression could significantly inhibit the proliferation of colorectal cancer cells. The expression levels of P65, P50, NF-κB downstream signaling proteins and the expression levels of proliferation-related genes c-myc, COX2, CCND1 and VEGFA were significantly up-regulated after overexpression of SNHG11. However, their expression levels were decreased significantly after knock-out of SNHG11. SNHG11 could up-regulate NF-κB complex and activate NFκB signaling pathway via binding to P50 in the NF-κB complex. Conclusion Long non-coding RNA SNHG11 promotes colorectal cancer cell proliferation by activating NF-κB signaling pathway. 

Key words: long non-coding RNA, SNHG11, NF-κB, colorectal cancer, proliferation