Research Advances in the Mechanisms of Fibrosis in Neurogenic Bladder Following Spinal Cord Injury

doi:10.3870/j.issn.1672-0741.25.03.008

Abstract

Abstract: Neurogenic bladder(NB)is the most common complication after spinal cord injury,often causing bladder storage and urination dysfunction,seriously affecting patients’daily life.Although current treatments for NB such as antimuscarinic drugs,botox injections,and surgery relieve NB symptoms,they are not effective in reducing cystic fibrosis progression.Cystic fibrosis is the key to cause irreversible changes in the structure of the bladder in the pathological process,so finding ways to alleviate cystic fibrosis is crucial for the treatment of NB.The inability of the bladder to accept neurotrophic factors,inflammatory response mediated by inflammatory factors and cell pyrodeath,and the activation of mechanically sensitive ion channels caused by mechanical stress of the bladder may be related to NB fibrosis after spinal cord injury.Understanding the molecular mechanism and potential activation pathway of NB fibrosis after spinal cord injury is expected to provide a new direction for the treatment of NB fibrosis.In this paper,the potential mechanism of NB fibrosis after spinal cord injury and the possible signaling pathway were reviewed in order to provide new ideas for clinical treatment and drug development.

Key words: spinal cord injury, neurogenic bladder, fibrosis

CLC Number:

R556.5

Jiang Jingjing, Li Yanjie, Yang Xinyu. Research Advances in the Mechanisms of Fibrosis in Neurogenic Bladder Following Spinal Cord Injury[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(3): 431-437.

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