Mechanism of Action of Bushen Ziyin Guchong Decoction Combined with Moxibustion and Auricular Pressure Beans in the Treatment of Metrorrhagiaof Kidney Yin Deficiency Type:A Randomized Controlled Trial

doi:10.3870/j.issn.1672-0741.25.07.023

Abstract

Abstract: Objective To evaluate the clinical efficacy,safety,and mechanism of action of Bushen Ziyin Guchong decoction combined with moxibustion and auricular point pressing in the treatment of menorrhagia of kidney yin deficiency type. Methods A randomized controlled trial was conducted in which 138 menorrhagia patients of kidney yin deficiency type were enrolled.The participants were divided into an experimental group(69 cases)and a control group(69 cases),with a 3-menstrual cycle intervention.The experimental group received oral Bushen Ziyin Guchong decoction plus moxibustion at Yinbai point(SP1)and auricular point pressing.The control group was orally administered drospirenone or ethinylestradiol Table Ⅱ.Clinical efficacy,sex hormones(FSH,LH,E2,PRL,P,T),angiogenic factors(VEGF,ANG-1),endometrial thickness,and safety indicators were compared between the two groups. Results The total effective rate of the experimental group was significantly higher than that of the control group(95.70% vs.84.10%,P<0.05).The experimental group outperformed the control group in reducing the levels of FSH,LH,E2,P,VEGF,and ANG-1;improving PBAC scores(99.44±47.20 vs.116.55±49.98);decreasing endometrial thickness(0.51±0.24 vs.0.64±0.26 cm);and lowering TCM syndrome scores(10.36±3.38 vs.12.42±1.37 points)(all P<0.05).The incidence of adverse reactions was lower in the experimental group(5.8% vs.17.4%,P=0.033). Conclusion Bushen Ziyin Guchong decoction combined with moxibustion and auricular point pressing significantly improves menorrhagia of kidney-yin deficiency type by regulating hypothalamic-pituitary-ovarian(HPO)axis function,inhibiting pathological angiogenesis,and repairing the endometrial structure.Compared with single Western medicine,it has superior efficacy and better safety.

Key words: menorrhagia, kidney-yin deficiency type, Bushen Ziyin Guchong Decoction, moxibustion, auricular pressure beans, randomized controlled trial

CLC Number:

R711.51

Dong Yongqi, Ruan Qianfang, Huang Xiaotao et al. Mechanism of Action of Bushen Ziyin Guchong Decoction Combined with Moxibustion and Auricular Pressure Beans in the Treatment of Metrorrhagiaof Kidney Yin Deficiency Type:A Randomized Controlled Trial[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(1): 11-19.

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