Protein Neddylation and Its Role in Tumor

doi:10.3870/j.issn.1672-0741.25.10.011

Abstract

Abstract: Neddylation is a significant post-translational modification that resembles ubiquitination and is a reversible protein modification process that is initiated by the cascade of three essential enzymes:E1,E2,and E3.By altering the stability,shape,subcellular localization,and function of target proteins,neddylation regulate a number of cellular biological processes.According to recent research,neddylation is generally overactivated in tumors,and its hub molecules are intimately associated with a number of malignant characteristics,including immune evasion,invasion and migration,and tumor cell proliferation.This opens up new potential targets for anti-tumor intervention efforts.This study focuses on a systematic analysis of neddylation,classifies its molecular mechanism and functional significance in carcinogenesis and evolution,and thoroughly examines its possible applications in tumor treatment.

Key words: neddylation, NEDD8, MLN4924, tumor

CLC Number:

R730

Yu Changqi, Zhang Ming, Deng Zhengdong et al. Protein Neddylation and Its Role in Tumor[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(3): 416-422.

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