Research Progress on the Role of Glucose Metabolism Disorder in Cerebral Small Vessel Disease

doi:10.3870/j.issn.1672-0741.25.09.014

Abstract

Abstract: Cerebral small vessel disease(CSVD)refers to a group of pathological processes affecting the small cerebral arteries,arterioles,capillaries,and venules of the brain,typically 40-200 μm in diameter.This disease is common in the elderly population and poses a significant threat to their health.Disorder of glucose metabolism is a key independent risk factor for CSVD progression.It can induce vascular endothelial dysfunction,disruption of the blood-brain barrier,and white matter injury through mechanisms such as insulin resistance,chronic inflammatory responses,and oxidative stress,thereby accelerating CSVD.This article reviews research advances on the role of glucose metabolism disorder in CSVD,aiming to provide a theoretical basis for the clinical treatment of CSVD and a reference for understanding its pathogenesis.

Key words: cerebral small vessel disease, glucose metabolism disorder, white matter injury

CLC Number:

R743

Li Yuqing, Yang Yi, Gong Xuanwei et al. Research Progress on the Role of Glucose Metabolism Disorder in Cerebral Small Vessel Disease[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(2): 284-289.

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