Research Advances in Targeting Protein Post-Translational Modifications to Regulate Pyroptosis for Osteoarthritis Therapy

doi:10.3870/j.issn.1672-0741.25.07.048

Abstract

Abstract: Osteoarthritis is a chronic bone and joint disease characterized primarily by the degenerative changes of articular cartilage.Current clinical treatments primarily focus on delaying disease progression and managing clinical symptoms;however,challenges remain in promoting cartilage regeneration and repair.Recent studies have indicated that pyroptosis plays a significant role in the pathogenesis of osteoarthritis.It exacerbates joint inflammatory responses and cartilage destruction by activating the NLRP3 inflammasome and releasing pro-inflammatory cytokines such as IL-1β.This review systematically elaborates on the molecular mechanisms by which post-translational modifications regulate pyroptosis.It focuses on how modifications such as ubiquitination,phosphorylation,acetylation,and SUMOylation dynamically regulate the assembly of the NLRP3 inflammasome and the activation of Gasdermin proteins,thereby modulating the process of pyroptosis.This aims to provide a new theoretical perspective for a deeper understanding of the pathogenesis of osteoarthritis and its treatment strategies.

Key words: osteoarthritis, post-translational modifications, pyroptosis, acetylation modification, ubiquitination modification

CLC Number:

R684.3

Niu Chaoyang, Cao Yujing. Research Advances in Targeting Protein Post-Translational Modifications to Regulate Pyroptosis for Osteoarthritis Therapy[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(2): 296-301.

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