Clinical Efficacy of Compound Sophora Decoction in the Treatment of Radiation Enteritis

doi:10.3870/j.issn.1672-0741.25.12.037

Abstract

Abstract: Objective To evaluate the clinical efficacy of Compound Sophora Decoction enema combined with conventional western medicine for the treatment of radiation enteritis.Methods A retrospective analysis was performed on 95 patients with radiation enteritis treated at the Department of Traditional Chinese Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,between January 2020 and December 2024.Patients were divided into control group(n=47,receiving conventional western medicine:dexamethasone and montmorillonite powder)and treatment group(n=48,receiving conventional treatment plus Compound Sophora Decoction enema once daily for one week).Traditional Chinese medicine(TCM)syndrome scores,serum inflammatory markers,and Karnofsky Performance Status(KPS)scores were compared between the two groups post-treatment.Results The overall symptom remission rate was significantly higher in the treatment group than in the control group(93.75%vs.78.72%,P<0.01).Following the treatment,both groups demonstrated significant improvements in TCM syndrome scores,serum inflammatory markers,and KPS scores(all P<0.05).Furthermore,the treatment group exhibited significantly greater improvements in these parameters compared with the control group(all P<0.05).Conclusion Compound Sophora Decoction enema combined with conventional western medicine significantly alleviates clinical symptoms,reduces systemic inflammation,and improves performance status in patients with radiation enteritis,offering a superior therapeutic outcome compared to conventional western medicine alone.

Key words: iradiation enteritis, Compound Sophora Decoction, enema, clinical research

CLC Number:

R818.8

Zhao Zhiqiang, Yu Zhouxin, Yu Ting, et al. Clinical Efficacy of Compound Sophora Decoction in the Treatment of Radiation Enteritis[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(4): 547-551.

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