The Application of the New Zebrafish Model in the Study of Intracranial Aneurysms

doi:10.3870/j.issn.1672-0741.25.07.045

Abstract

Abstract: Traditional animal models have inherent limitations in the genetic manipulation,developmental visualization,and high-throughput screening for intracranial aneurysms(IAs).The emergence of the zebrafish model has been expanding the experimental approaches and research platforms available in these fields.This review systematically analyzes the biological basis of using zebrafish to investigate human cerebrovascular diseases,summarizes several established zebrafish aneurysm models,and introduces their applications in studies of IA mechanisms.Unlike previous reviews that mainly compared the construction methods and strengths of different models in parallel,this paper also focuses on the applications of zebrafish aneurysm models in studying disease mechanisms,aiming to promote a broader application in IA pathogenesis research and drug screening.

Key words: intracranial aneurysm, intracerebral hemorrhage, zebrafish, PDGFRB

CLC Number:

R651.122

Zheng Yang, Ning Guozhu, Zhang Jingjing. The Application of the New Zebrafish Model in the Study of Intracranial Aneurysms[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(1): 122-128.

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