Mechanism of the Nrf2 Pathway Against Oxidative Stress in Common Peripheral Neuropathy

doi:10.3870/j.issn.1672-0741.24.10.066

Abstract

Abstract: Peripheral neuropathies are a collection of disorders characterized by injury and generalized dysfunction of nerves.Pathogenic factors are complex,including trauma,hyperglycemia,side effects of chemotherapeutic drugs and inflammatory,immune-related,metabolic,endocrine-related,and neoplastic factors.In addition,it can cause great problems for patients.Oxidative stress,as one of the key causes of peripheral neuropathy,is characterized mainly by an imbalance between oxidative processes and antioxidant defenses in the body,which tends to oxidize,leading to inflammatory infiltration of neutrophils,increased protease secretion,and the production of many oxidative intermediates.At present,antioxidants are widely used in clinical practices to inhibit oxidative stress to improve peripheral neuropathy,but their efficacy is limited.Nuclear factor-erythroid 2-related factor 2(Nrf2),a key transcription factor of intracellular oxidative stress,mediates antioxidant effects through numerous signaling pathways,such as the Nrf2/HO-1,Nrf2/NQO1,PERK/Nrf2,Nrf2/ERK,and Nrf2/NF-κB pathways.In the present study,the oxidative stress pathways associated with the targeting of cellular Nrf2 factors were reviewed,hopefully providing evidence for peripheral neuropathy-related research.

Key words: oxidative stress, peripheral neuropathy, Nrf2 pathway

CLC Number:

R745

Fu Qingwen, You Haojun, Lei Jing. Mechanism of the Nrf2 Pathway Against Oxidative Stress in Common Peripheral Neuropathy[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2026, 55(1): 140-145.

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